Aim To explore the cardiovascular structure and function of ultrasonograph, blood-fat of healthy people by non-invasive ways, and analyze its action mechanism of arteriosclerosis. Methods 855 healthy people coming from 3 cities of Shenyang, Dalian and Beijing, were divided into 4 groups:≤44 years old group, 45~59 years old group, 60~74 years old group and ≥75 years old group. 55 items including life style, dietary structure, blood pressure, heart and carotid ultrasonograph, biochemistry, were measured to observe their changing with advancing age. Results 8 items including pulse pressure (PP), carotid artery intima-media thickness (IMT), carotid artery internal diameter (D), mitral valve anulus anterior wall A (MVAA), mitral valve anulus lateral wall E (MVLE), total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL) were correlated with aging significantly (r value was 0.521, 0.425, 0.258, 0.17, -0.25, 0.274, 0.181, -0.251 respectively with all P<0.01). Conclusions PP, IMT and carotid artery internal diameter are independent factors of the cardiovascular structure and function; IMT is the change of arteriosclerosis at earlier period; TC is the important risk factor of arteriosclerosis.