Aim To observe the correlation between the level of serum homocysteine and the heart failure in patients with coronary heart diseases and the severity of heart failure.Meanwhile the interventional treatment of folic acid and vitamin B6,B12 were given to the heart failure patients to observe the changes of HCY and the heart failure after the short-term therapy.Methods All 57 patients with chronic heart failure secondary to coronary heart diseases(heart failure group)were divided into three subgroups according to NYHA cardiac function classification(abbreviated as coronary heart function Ⅱ,Ⅲ,Ⅳ groups).Twenty patients who were diagnosed as stable angina pectoris without heart failure were selected as coronary heart disease control group(CHD control group).20 healthy subjects after examination served as healthy control group.The levels of HCY and NT-proBNP were measured.Results ①The prevalence rate of hyperhomocysteinemia(HHCY)was higher in chronic heart failure group than that in CHD control group and the healthy control group.②The serum HCY in patients with chronic heart failure disease were higher than that in stable angina pectoris patients and both higher than that in the healthy people.③ In heart failure group the serum HCY were increased with the NYHA cardiac function classification increase(P<0.05).④ The serum HCY and NT-proBNP was positive linear correlation.⑤In heart failure group,the serum HCY and EF were determined with negative linear correlation;the serum HCY and LVEDD were determined with negative linear correlation.⑥After short-term treated with folic acid,vitaminB6 and B12,the levels of HCY and NT-proBNP were both decreased.Conclusion HHCY are associated with heart failure and maybe one of the independent risk factors of heart failure.The level of HCY is increased with the severity degree of the cardiac function and the serum HCY may participate in the development of heart failure.Both levels of HCY and NT-proBNP seem to be related with the prognosis of heart failure.