Aim To observe the effect of Huoxueyihao capsule combined with Levamlodipine on pre-thrombus state of hypertension 2.Methods 152 patients with hypertension 2 were divided into Levamlodipine group,aspirin group and huoxueyihao group,and treated by Levamlodipine Besylate tablet,Levamlodipine Besylate tablet and aspirin enteric-coated tablet,Levamlodipine Besylate tablet and Huoxueyihao capsule for 8 weeks respectively.The levels of blood pressure,nitric oxide(NO),von willebrand factor(vWF),granule membrane protein-140(GMP-140),plasma fibrinogen(Fg)were observed before and after treatment.Results Contrast in the health group,the levels of NO in patients were remarkably decreased(P<0.05),but the levels of vWF,GMP-140 and Fg were markedly increased(P<0.05).The levels of NO in the treated patients were all higher than those of before treatment(P<0.05),and the levels of Huoxueyihao group rise obviously(P<0.05).The levels of vWF,GMP-140,Fg all decreased after treatment(P<0.05),and those in Huoxueyihao group decreased especially(P<0.05).Conclusion Huoxueyihao capsule combined with Levamlodipine could be used in treating pre-thrombus state of hypertension 2 through protecting vascular endothelium and stabilizing platelet function.