Aim To explore the relationship of serum uric acid(UA),fibrinogen(FIB),low density lipoprotein(LDL)and lipoprotein(a)[Lp(a)] and severity of coronary artery lesions in patients with different types of coronary heart disease(CHD).Methods The investigated population were consisted of 185 cases of CHD patient,including 107 cases of acute coronary syndrome(ACS),30 cases of coronary artery spasm(CAS),48 cases of stable angina pectoris(SAP),and 31 normal controls(NC).Serous UA,LDL and Lp(a)were detected with Hitachi-7600 Auto-analyzer,and FIB was deteced with BE-Thrombolyzer.The severity of coronary artery lesions was quantified with the Gensini score system and the number of impaired arteries.Results Compared with that of NC group,the levels of serous UA were increased in the patients with CAS,SAP and ACS in male;the same phenomenon was observed in SAP and ACS in female.The FIB level was significantly higher in the ACS patients than in NC group and SAP patients.The levels of UA,FIB and LDL were related to the Gensini score,the UA and FIB were related to the number of impaired arteries.Conclusions There were different levels of UA and FIB in different types of CHD and LDL was related to the Gensini score of coronary artery stenosis.