Aim To discuss the changes and significance of plasma fibrinogen and D-dimer in patients with acute cerebral.Methods The levels of plasma fibrinogen and D-dimer in 96 cases of acute cerebral infarction and 30 healthy controls were detected with Clauss method and immunoturbidimetry method,respectively.Results The levels of plasma fibrinogen and D-dimer were significantly higher than those in the control group(P<0.05).Moreover,with the aggression of acute cerebral infarction,the levels of fibrinogen and D-dimer were increasing,gradually(P<0.05).The levels of fibrinogen were positively correlated with the levels of D-dimer(r=0.423,P<0.05).Conclusion The levels of plasma fibrinogen and D-dimer are useful for the diagnosis and evaluation of disease severity.