Aim To study the the therapeutic efficacy and safety of amlodipine in the therapy for renal hypertension. Methods 76 patients of renal hypenension with chronic renal failure were diagnosed to be treated with amlodipine for 12 weeks and compared with captopril. The initial dose was 5 mg Q12h,the maximal dose was 10 mg Q12h. the captopril dose was 25 mg Q 8h. The blood pressure,renal function,urea protein,heart rate,administration status and adverse reactions of the patients were observed during treating time. Results After 12 weeks of treatment,the blood pressure in amlodipine group was reduced by(23.00±5.28)/(19.29±2.31) mmHg. The total effective rate in amlodipine group 92.11%(70/76) respectively. The total adverse incidence rate in amlodipine group was 9.21%(7/76).While the blood pressure in captopril group was reduced by(11.90±4.18)/(11.80±2.29) mmHg. The total effective rate in captopril group was 61.67%(37/60) respectively. The total adverse incidence rate in captopril group were 16.67%(10/60). There were no obvious changes of heart rate and renal function after treatment and no obvious adverse event was showed in amlodipine group. Conclusion Amlodipin has a better eficacy and is safe in the therapy of chronic renal failure patients with renal hypertension.