Aim To discuss the correlation factor of carotid angiosclerosis plaque in the patients with type 2 diabetes mellitus(T2DM). Methods 123 cases of patients with T2DM,including non-carotid angiosclerosis plaque and carotid angiosclerosis plaque,were explored by color ultrasonoscope.The physical examinations included measurement of age,diabetes course,body mass index,blood pressure,smoking history,hypertension history,microangiopathy,carotid intima-media thickness,etc.Laboratory tests included serum C-reactive protein(CRP),fasting blood glucose,total cholesterol,triglycerides,high density lipoprotein cholesterol,low density lipoprotein cholesterol,atherogenic index of plasma,uric acid and serum creatinine. Results The levels of serum CRP(P<0.05),age(P<0.01),carotid intima-media thickness(P<0.01) and microangiopathy incidence(P<0.05) in angiosclerosis plaque group were higher than those in non-angiosclerosis plaque group.Stepwise regression analysis of relative factors for carotid angiosclerosis plaque showed that only the carotid intima-media thickness was significantly associated with the carotid angiosclerosis plaque(P<0.05). Conclusions Carotid angiosclerosis plaque may be related to carotid intima-media thickness,age and CRP in the patients with T2DM.Carotid intima-media thickness may be a risk factor of carotid angiosclerosis plaque.Micrangium complication incidence will be raised accompanying with the formation of carotid angiosclerosis plaque.