Aim To determine the effect of atorvastatin on macroangiopathy in patients with type 2 diabetes mellitus(DM) and further to explore the possible mechanism. Methods 120 patients with DM were enrolled in the present study and randomly divided into routine treatment group and atorvastatin treatment group.Flow-mediated dilation(FMD) and intima-medial thickness(IMT) was measured before treatment and after 6-month treatment.The levels of plasma monocyte chemoattractant protein-1(MCP-1),nitric oxide(NO),and vonwillebrand factor(vWF) were also determined. Results After 6 months therapy,the levels of blood glucose and blood pressure were well controlled in two groups.FMD and the levels of NO and vWF were also improved in both groups.However,compared with routine treatment group,endothelial function was more significantly improved by treatment with atorvastatin(P<0.05).Atorvastatin treatment controlled blood lipid,attenuated the levels of MCP-1 and the progress of IMT(P<0.05),but routine treatment had no effect. Conclusion Atorvastatin may induce a markedly protective effect on the macroangiopathy of DM,which may be related to regulating blood lipids,protecting vascular endothelium and inhibiting vascular inflammation.