AimTo investigate the association between apolipoprotein B(ApoB) gene polymorphism and coronary heart disease with diabetes in Han and Uygur.MethodsUsing PCR-LDR,we detected the genotypes of EcoRⅠ of ApoB gene in 136 unrelated healthy individuals and 266 patients with evidence of CHD, which included 154 diabetes.The relation of gene polymorphism ApoB and levels of serum lipids, apolipoproteins was also studied.ResultsNeither the frequencies of genotypes nor those of alleles of ApoB gene EcoRⅠ polymorphism was statistically different between patients and controls (P>0.05), both in Uygur and Han in CHD and CHD with diabetes.No relation was found between A allele and lipid level.ConclusionThe EcoRⅠ polymorphism of ApoB gene maybe affect the levels of serum lipids and lipoproteins, but were not major genetic factors of CHD and CHD with dibetes in Han and Uygur.