Aim To explore the association of lecithin:cholesterol acyltransferase(LCAT)gene polymorphism with the occurrence of familial aggregation of cerebral hemorrhage and lipid.Methods LCAT gene 608C/T polymorphism was detected by polymerase chain reaction(PCR)and restriction fragment length polymorphism(RFLP)in 10 families of cerebral hemorrhage with family history(CHFH)including 30 cerebral hemorrhage patients(CHFH-P),38 first degree relatives(CHFH-Ⅰ),31 second degree relatives(CHFH-Ⅱ),27 third degree relatives(CHFH-Ⅲ),100 patients with sporadic cerebral hemorrhage(SCH)and 100 healthy controls.Results The distribution of LCAT 608C/T gene polymorphism was in accordance with Hardy-Weinberg balance in the three groups.The CT genotype frequency and T allele frequency in familial aggregation of cerebral hemorrhage group,sporadic cerebral hemorrhage group were not significantly higher than those in control group.The serum level of high density lipoprotein cholesterol(HDLC)in 608CC genotype subgroup was significantly higher than that in 608CT genotype subgroup of the same group in familial aggregation of cerebral hemorrhage group,sporadic cerebral hemorrhage group(P<0.05).Conclusion There is probably no association of 608C/T polymorphism of LCAT gene with familial aggregation of cerebral hemorrhage in han population of Hunan province.T alleles of 608C/T are possibly associated with the metabolism of HDLC.