Diabetic subjects exhibit an increased propensity to develop a diffuse and extensive pattern of arteriosclerosis.However,its mechanisms are still poorly understood.There is evidence to suggest that oxidization of low density lipoprotein(LDL)accelerated the progression of diabetic vasculopathy.Lectin-like oxidized low density lipoprotein receptor-1(LOX-1)is a newly identified receptor for oxidized LDL and it is up-regulated in diabetic condition.Some studies have shown that drugs commonly used in the treatment of diabetic patients inhibit endothelial LOX-1 expression.This review summarizes the function of LOX-1 in diabetic macrovascular disease,its regulation mechanisms and therapeutic approaches.