Aim To evaluate the left ventricular functions of acute organophosphate poisoning patient(AOPP)using mitral annular motion velocities measured by Doppler tissue imaging (DTI). Methods Tissue Doppler velocity mode was used to observe mitral annulus movement in 78 cases with AOPP and 32 healthy adults. After mitral annular pulsed-wave rate of E/A were measured by traditional echocardiographic,the peak value of mitral annular early diastolic velocity (Em),late diastolic velocity(Am)were analyzed by DTI. Results E/A>Em/Am>1 was observd in health control group as well as the mild-moderate AOPP; Em/AmP><0.001). Conclusion The left ventricle function,in terms of contraction and relaxation,was decreased in the cases with severe AOPP compared with health control group and mild-moderate group. TDI is a useful tool to assess left ventricle function in the cases with AOPP.