Aim To investigate the relationship between hypertriglyceridemia (HTG) and hyperhomocysteinemia (HHcy) in patients with chronic kidney disease. Methods 173 cases of chronic kidney disease (CKD) patients with blood samples were collected to detect the creatinine,blood lipids,homocysteine (Hcy) and other values,and in accordance with the level of creatinine and TG were divided into four groups:normal triglyceride (TG) level group in renal compensatory,HHcy in renal compensatory,normal TG level group in renal decompensatory and HHcy in renal decompensatory. Results Hcy levels were significantly higher in HTG group than that in normal TG group (P><0.05),but the correlation analysis showed that there was no significant correlation (P>0.05). Conclusion HTG and HHcy is not correlated in patients with chronic kidney disease.