Visfatin is a newly found novel adipokine having high expression in adipocyte. It not only can produce insulin-like effect,but also is related to oxygen deficit,vulnerable plaque rupture,endothelial disfunction,angiogenesis,inflammation and metabolism of glucose and lipid. Visfatin may play an important role in the progress of atherosclerosis. The finding of vistatin will provide new ideas in studying the atherosclerosis-related diseases,which will provide new target for the atherosclerosis-related disease therapy.