Universal human is susceptible to helicobacter pylori (HP). Many studies declare that the prevalence of HP is higher in diabetes patients than that in non-diabetes,and HP infection is a risk factor of cardiocerebrovascular disease and peripheral vessel disease in diabetes patients. But other studies show that HP infection is not associated with diabetes mellitus and large vascular disease in diabetes patients. The relationship between HP infection and large vascular disease in diabetes need to be further researched.