Aim The present study was aimed to analyze the associations between plasma adiponectin,hemeoxygenase-1 and severity of coronary artery lesions in patients with coronary artery disease to explore the interaction between adiponectin and hemeoxygenase-1. Methods The plasma levels of adiponectin and hemeoxygenase-1 were determined by ELISA in the coronary artery disease group including 81 patients and the control group including 35 patients. Correlations were analyzed between these two biochemistry marks and the severity of coronary artery lesions(Gensini integrals). Results Plasma levels of adiponectin and hemeoxygenase-1 of coronary artery disease group were significantly lower than that of control group(4.87±0.24 vs 13.51±0.93 mg/L,P><0.001;38.85±2.86 vs 220.00±28.11 μg/L,P><0.001). Plasma levels of adiponectin and coronary artery disease in patients with more coronary artery lesions were also significantly lower than the patients with less coronary artery lesions after classification by the number of coronary artery lesions. Adiponectin was significantly associated with coronary artery disease positively(r=0.551,P><0.001). Gensini integrals was significantly correlated with adoponectin and hemeoxygenase-1 negatively(r=-0.526,P><0.001; r=-0.451,P><0.001). Conclusion Plasma adiponectin and hemeoxygenase-1 were closely associated with each other and with the severity of coronary artery lesions in patients with coronary artery disease. There're possible regulatory interactions between adiponectin and hemeoxygenase-1.