Aim To discuss the changes of ankle brachial index (ABI),brachial-ankle pulse wave velocity (baPWV) and high sensitive C-reactive protein (hs-CRP) in 195 patients with different risk factors of atherosclerosis,and analyse its effect in the diagnosis of coronary heart disease (CHD). Methods 195 patients with possible diagnosis or having been diagnosed as coronary heart disease (CHD) with at least a merger of atherosclerosis risk factors who were hospitalized Affiliated Hospital of Ningxia Medical University on November 2008-2009 November were selected and divided into coronary artery disease (CAD) group (150 cases) and non-CAD group (45 cases). Then according to at least one coronary stenosis ≥ 50%,CAD group was divided into ≥50% group (97 cases) and <50% group (53 cases). The atherosclerosis risk factors were recorded and ABI,baPWV,hs-CRP of serum were measured. 39 healthy cases were chosen as control. Results In CAD group,non-CAD group and control group ABI had no significant difference (P>0.05),baPWV had statistically significant difference (P><0.01) and there were significant differences between the ≥50% group and <50% group (P><0.01). In non-CAD group and control group hs-CRP had no significant difference (P>0.05). However,in CAD group hs-CRP levels were significantly higher than the other two groups,there were significant differences between the two groups (P><0.01),the level of hs-CRP showed no significant difference between the two subgroups of CAD group (P>0.05). With coronary angiography as the gold standard for drawing ROC curve,ABI had no significant predictive value for CAD. CHD with higher baPWV had the predictive value with the cut-off point of 1700 cm/s,hs-CRP had a moderate predictive value with its cut-off point of 0.67 mg/L. For the combination of baPWV and CRP,the sensitivity rate was 98.0%,the specific rate was 95.8%,misdiagnosis rate was 4.2%,miss rate was 2.0%,positive predicatire value was 99% and negative predicative value was 92%,which had higher diagnostic value. Conclusions ABI and CHD was not related. baPWV increases with the extent of CHD,which had higher predictive value for CHD. hs-CRP had moderate predictive value for CHD.