Aim To observe ghrelin level variation of metabolic syndrome patient and the relationship with inflammatory factor. Methods According the definition of 2005 international diabetes mellitus association,the people were divided into metabolic syndrome (MS) group and control group. RIA method was used to measure ghrelin,and ELISA method was applied to measure inflammatory factor level. The different ghrelin level of the two groups was compared,and the relationship of ghrelin and endothelial relaxation function and inflammatory level were analyzed. Results The ghrelin levels of MS group were lower than that of control group(P><0.001). The endothelial relaxation function of 1st quartile ghrelin was lower than that of 4 th quartile ghrelin; the inflammatory factor TNF-α,IL-8,MCP-1 concentrations of 1st quartile ghrelin were higher than those of 4 th quartile; correlation analysis demonstrated that ghrelin level were positively related with endothelial relaxation function,and negatively related with the inflammatory functions; multiple regression analysis suggested that the most influence ghrelin level was triglyceride,the next was systolic pressure,then age. Conclusions The ghrelin level of MS were decreased,and positively correlated with endothelial relaxation function,negatively correlated with inflammatory factor. Ghrelin may improve endothelial relaxation fuction,decrease inflammatory factor level,and prevent the development of MS.