Aim To observe telmisartan and atorvastatin's association influence on the expression of hepatocyte growth factor of blood vessel and the vascular endothelial cell's morphology and function in diabetes rats which can supply with laboratory material for preventing and caring artherosclerosis of patients with diabetes in early stage during clinic practice. Methods Animal model of the diabetes rats were built and divided into different groups which were given different medicine intervention,and the expression of hepatocyte growth factor was tested and the morphology of endothelium within each group was observed,then the results of each group were compared. Results Compare to normal group,the diabetes groups manifested lower concentration of hepatocyte growth factor,mRNA expression of hepatocyte growth factor decreased and the endothelium's necrosis falling off from blood vessel were observed under transmission electron microscope.Compared to pure diabetes group,the groups with medicine intervention,either single telmisartan or telmisartan associated with atorvastatin,both had higher hepatocyte growth factor concentration level and hepatocyte growth factor mRNA expression,the morphy of blood vessel endothelium become much better and normalizing.Compared to single telmisartan group,the hepatocyte growth factor concentration and hepatocyte growth factor mRNA expression were much higher in the group of telmisartan associated with atorvastatin,the morphology of endothelium was more normalizing. Conclusion Telmisartan associated with atorvastatin can improve the morphology of endothelium better than single telmisartan,which is worthy of the further research in the clinical prevention and treatment of atherosclerosis of patients with diabetes in early stage.