Aim To investigate the effects of fetal intrauterine chromic hypoxia on the blood pressure of offspring rats. Methods Pregnant Sprague-Dawley rats were subjected to hypoxia for 3 hours in low pressure cabin with an oxygen concentration of 10%±1% from day 7 to day 21 of pregnancy.The body weight,organs weight and blood pressure were determined in the offspring rats. Results Fetal hypoxia offspring growth were retarded at birth(P><0.01) but had similar weight to controls at 20 days of age.There were significant declines in liver weight of offspring at birth and 20 days of age,and significant decreases in kidney weight of male offspring at 3 and 7 months of age(all P><0.05).Systolic blood pressures were significantly elevated in male hypoxia offspring rats at 5 and 7 months of age as compared with controls(all P><0.05),and aggravated with age.But it was not significantly different from controls in female hypoxia offspring rats. Conclusion Intrauterine chromic hypoxia may be a stress factor for fetal programming in rat liver,kidney and vascular tissues. It can induce the increased blood pressure in the male offspring rats,which aggravated with age and displayed a gender related character.