Aim To investigate the relationship between the single nucleotide polymorphism(SNP) of TNFRSF1B gene and coronary heart disease(CHD) in Chinese population. Methods The polymerase chain reaction-ligase detection reaction(PCR-LDR) was used to detect TNFRSF1B gene rs1061624 in the 104 controls and 208 coronary heart disease patients. Results The frequency of this polymorphism was consistent with the law of Hardy-Weinberg.The frequency of rs1061624 genotype did not differ between the patients and the controls(13.7% vs 18.2%,P>0.05).These results was independent on age,gender,hypertension,diabetes and hyperlipidemia. Conclusion The results support that there is no significant correlation between the polymorphism of TNFRSF1B rs1061624 and coronary heart disease.