Aim Measurable C-reactive protein using high sensitive method was so called high-sensitivity C-reactive protein.C-reactive protein plays an increasingly important role in the diagnosis and prediction of coronary heart disease and peripheral vascular disease according to a number of researches,more and more studies have revealed C-reactive protein directly involved in cardiovascular diseases,such as inflammation and atherosclerosis.Furthermore,it is one of the most powerful predictors of cardiovascular disease risk factors.All kinds of inflammation,tissue infection and damage will increase the levels of several plasma proteins in circulation,including C-reactive protein as an acute phase reactive protein,and its increased level is a sensitive indicator of inflammation in vivo.As it's known,inflammation plays an important role in the development and progression of atherosclerosis and cardiovascular disease.The relationship and mechanism between hs-CRP and atherosclerosis will be described in this article.