AimTo investigate the association between 7 single nucleotide polymorphisms in intron 2 of hyperplasia suppressor gene (HSG) and essential hypertension.Methods500 normotensive subjects (NT group) and 930 essential hypertensive patients (EH group) were screened and DNA was acquired from white blood cells.Real-time quantitative PCR was used for the detection of 7 SNPs in intron 2 of HSG.ResultsThe results showed that genotypes distribution and allelic frequency of rs873457, rs2336384 and rs4846085 were significantly different (p<0.05) between EH group and NT group, TT∶TC∶CC=21.8%∶46.6%∶31.6%/22.5%∶53.0%∶24.5% (rs873457), CC∶CA∶AA=21.8%∶46.8%∶31.4%/22.8%∶52.6%∶24.6% (rs2336384), TT∶TC∶CC=22.6%∶46.4%∶31.0%/23.4%∶51.8%∶24.7% (rs4846085) for genotypes distribution frequency and T∶C=45.1%∶51.0%/49.0%∶51.0% (rs873457), C∶A=45.2%∶54.8%/49.1%∶50.9% (rs2336384), T∶C=45.8%∶54.2%/49.1%∶50.6% (rs4846085) for allelic frequency.When subgrouped by sex, the genotypes distribution and allelic frequency of all the SNP were significantly different in male (p<0.05 or p<0.01) but not in female groups (p>0.05).Correlation analysis indicated that body mass index (BMI), age and genotype were related with essential hypertension.Logistic regression showed that BMI and rs873457 were closely associated with blood pressure after adjusting for age.The frequency of C-G-A-A-A-C-C haplotype was significantly higher in essential hypertensive patients verse control individuals, either in entire population, in male or female group (p<0.01 for all).As for other haplotypes, most of haplotypes were only significantly different in the entire population and male subjects.ConclusionThe genetic variations of HSG may be associated with essential hypertension in male Chinese.