Remnant-like lipoprotein particles have been implicated as potentially atherogenic lipoproteins. A variety of proinflammatory adipocytokines secreted by adipocytes play an important role in the development of chronic inflammation of atherosclerosis. Obesity is an independent risk factor of coronary heart disease and atherosclerosis. Remnant-like lipoprotein particles accelerate atherosclerosis events through stimulating the release of proinflammatory adipocytokines and inducing adipogenic differentiation from preadipocytes to mature adipocytes. In addition, the effects of adipocytes on remnant-like lipoprotein particles metabolism may impact the atherogenic intensity of remnant-like lipoprotein particles in vivo.