AimTo investigate the plasma levels of periostin protein and vascular endothelial growth factor (VEGF) in the patients with coronary heart disease (CHD), and to analyse the relationship and clinical significance between periostin protein and VEGF.Methods Plasma levels of periostin protein and VEGF in CHD patients (n=180) and healthy controls (n=52) were measured by enzyme-linked immunosorbent assay (ELISA). The patients with CHD were divided into four gropus: acute myocardial infarction (AMI)group (n=58), old myocardial infarction (OMI) group (n=30), unstable angina pectoris (UAP) group (n=40) and stable angina pectoris (SAP) group (n=52).ResultsThe plasma levels of periostin were not only significantly higher in CHD patients compared to healthy controls in the order of AMI group>UAP group>OMI group>SAP group> healthy controls, but also had statistical significance except OMI group vs SAP group and UAP group vs OMI group (p<0.05 or p<0.01). The plasma levels of VEGF were significantly higher in CHD patients compared to healthy controls in the order of AMI group>UAP group>OMI group>SAP group> healthy controls ( p<0.05 or p<0.01 ). The plasma levels of periostin was positively correlated with VEGF (r=0.593，p<0.01).ConclusionsThe plasma levels of periostin significantly correlated with CHD. The increase in plasma levels of periostin may be one of the pathogenesis of coronary heart disease, and periostin may promote