AimTo investigate the association of P-selectin gene single nucleotide polymorphisms (SNP) and susceptibility to acute myocardial infarction (AMI) in a Chinese population, and to analyze association of serum levels and genotypes of P-selectin with AMI.Methods P-selectin gene －2123 G/C single nucleotide polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing among 150 AMI patients and 160 age and sex matched controls in a Chinese population, and serum level of P-selectin was determined by enzyme-linked immunosorbent assay (ELISA).ResultsSerum levels of P-selectin in AMI patients were significantly higher than those of controls (p<0.05), the distributions of P-selectin gene －2123 G/C polymorphism were significantly different between AMI group and control group (p<0.05). The relative risk suffered from AMI of －2123 C allele was 1.625 times of the G allele carriers (OR=1.625, 95%CI was 1.177～2.244, p=0.003); the serum levels of P-selectin C allele carriers was significantly higher than no carriers (p<0.05).ConclusionsP-selectin gene －2123 G/C polymorphism was associated with AMI, －2123 C allele is an important genetic susceptibility gene for AMI. In which the P-selectin C allele carriers may increase risk by enhancing the P-selectin expression in the pathogenesis of AMI.