Aim To study the clinical effects of atorvastatin treatment on chronic heart failure of non-ischemic heart disease,as the basis for clinical treatment of the disease. Methods 93 cases with chronic heart failure of non-ischemic heart disease from January 2008 to June 2010 Division I hospital for treatment were selected,and in accordance with the treatment randomly divided into treatment group and control group.Heart function and cardiac indices were observed and compared before and after treatment in the two groups. Results The total effective rate was 89.13%(41/46) in the treatment group,while the control group was only 63.83%(30/47).The total effective rate in the treatment group was higher than that in the control group(P<0.05).Before treatment,LVEF and LVDD had no significant difference in the two groups(P>0.05).After treatment,LVEF and LVDD were significantly improved in the two groups(P<0.05),and the improvement of LVEF and LVDD in the treatment group were better than those in the control group(P<0.05). Conclusions Atorvastatin treatment of non-ischemic heart disease with chronic heart failure has a good therapeutic effect,which can be widely applied in clinical practice.