Aim To investigate the relationship between the thromboxane A2 receptor(TXA2R) gene polymorphism(rs768963) and platelet aggregation in Han people in Shanghai. Methods TXA2R gene types,tested by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP),as well as platelet aggregation of 59 cerebral infarction patients and 40 health controls were detected. Results Triglyceride(TG) and blood pressure of cerebral infraction group were significantly higher when high density lipoprotein cholesterol(HDLC) was lower than that of health control(P<0.05).Mutant of TXA2R(CT and CC) improves the platelet aggregation(1') in health control group and platelet aggregation(1' and max) in cerebral infarction group,compared with wild type(TT).Studied as a whole group,mutant of TXA2R also had more significant impact on the platelet aggregation(1' and max) than wild type. Conclusion Compared with wild type,mutant of TXA2R(rs768963) improves the platelet aggregation,which may increase the incidence of thrombosis.