Aim To investigate the risk factors of contrast-induced Nephropathy(CIN) in the percutaneous coronary intervention(PCI). Methods To collect the clinical data of 172 patients who underwent the PCI from January,2008 to December,2009,compare contrast agents dose,recorded the creatinine(Cre) before and after treatment,and analyse the risk factors for occurrence of CIN. Results There were 32 cases occurred CIN,including 21 cases(13%) with GFR >60 mL/min,and 19 cases(40%) with GFR<60 mL/min(P<0.001).The incidence rate was 18.61 %(32/172).The following variables may be the significant factors correlating with CIN: aged≥75 years,three teams of coronary lesions,LVEF<40%,Cre<133 μmol/L and contrast agents dose>300 mL(P<0.001).The incidence of CIN in those patients who had renal dysfunction combining with diabetes mellitus or hypertension was higher than those without renal dysfunction(P<0.01). Conclusion renal damage and the degree of it are the most significant risk factors of CIN development after PCI.Renal insufficiency,aged≥75 years,multivessel coronary artery disease,LVEF<40%,and contrast agents dose>300 mL,are all independent risk factors of CIN.Patients with diabetes or hypertension and pre-existing renal insufficiency have a greater risk of CIN.