Aim To observe the change of serum Apelin,PON1 and malondialdehyde(MDA) in arteriosclerosis with type II diabetes patients. Method Carotid artery and lower extremity artery ultrasonic doppler were performed on patients with type II diabetes from Jun 2008 to Jun.2010.40 non-atherosclerosis cases were divided into non-atherosclerosis group,while 160 cases with atherosclerosis were divided into atherosclerosis group.They were further divided into four groups according to their grade of atherosclerosis,42 cases of grade Ⅰ,39 of grade Ⅱ,41 of grade Ⅲ,and 38 of grade Ⅳ.40 health cases during the same period were chosen as control group.The level of serum Apelin,PON1 and MDA in each group were compared. Result Grade I group had no obvious change with control group in serum Apelin,PON1 and MDA(P>0.05);Apelin and PON1 in gade Ⅱ,grade Ⅲ and grade Ⅳ group were significantly lower than those in control group,and MDA was higher than control group(P<0.01);Apelin,PON1 and MDA in gade Ⅱ,grade Ⅲ and grade Ⅳ group had significant difference(P<0.05). Conclusion The decrease of Apelin and PON1 is the warning factor of atherosclerosis in type 2 diabetes patients.