Aim To investigate the role of lipoprotein lipase(LPL) activator NO-1886 on the protein expressions of tumor necrosis factor-α(TNF-α) and IL-1β in high-fat/high-sucrose/high-cholesterol diet(HFSCD) fed miniature pigs.Methods Male,fifteen Bama-miniature pigs were randomized into three groups:control group,high-fat/highsucrose/high-cholesterol(three high) group and NO-1886 treated(HFSCD + NO-1886) group.Blood samples for plasma parameters including plasma TG and FFA were withdrawn from the orbital sinus of the animals at the end of each month following an overnight fast.The pigs were sacrificed at the end of month 5.The degree of lipid deposition in liver was examined by transmission electron microscope.The protein levels of TNF-α and IL-1beta in liver and fat tissues were measured by western blotting.Results The lipid metabolic disorder was induced in Guangxi Bama-miniature pigs by feeding high fat/high sucrose/high cholesterol diet,levels of plasma fasting TG and FFA were increased,which induced ectopic visceral lipid deposition in liver tissue and increased the protein levels of TNF-α and IL-1βin liver and fat tissues.While NO-1886 decreased the level of TG and FFA,ameliorated visceral fat deposition and reduced the protein expres-sions of TNF-α and IL-1beta in liver and fat tissues.Conclusions NO-1886 may significantly meliorate ectopic visceral lipid deposition,ameliorated lipid metabolism,decrease the protein expressions of TNF-α and IL-1β in tissues of high-fat/high-sucrose/high-cholesterol diet fed miniature pigs,and inhibit the progress of atherosclerosis.