Aim To evaluate the correlation between the left antetior descending coronary artery(LAD) atherosclerotic stenosis and cardiac function by 64-slice spiral CT,and to discuss the mainly imaging findings.Methods 104 cases with the LAD atherosclerotic stenosis and 20 cases of controls were studied.All cases underwent 64-row CT coronary angiography,and the data were transferred to Vitrea 2.0 work station.Then,the parameters including left ventricular ejection fraction(LVEF),left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV),left ventricular myocardial mass(LVMM) were calculated.All data were analyzed with statistical software.Results There were no significant difference of cardiac functions in mild stenosis group compared with control group,and in moderate stenosis group,LVMM and LVESV increased,while LVEF decreased in a small percentage.Statistical differences of LVEF,LVEDV,LVESV,LVMM could be found in severe stenosis group compared with mild stenosis group,moderate stenosis group and the control group.Conclusion With the stenosis of the LAD increasing,the change is a dynamic process from chronic adjustment to cardiac dysfunction.64-slice spiral CT can evaluate the changes and correlations accurately.