How components of metabolic syncrome(MS) progress to coronary atherosclerotic heart disease(CAD) is still unclear.Adponectin,a fat-derived plasma protein,is recently considered as a link between MS and CAD,as a number of studies reveal that decreased adiponectin level is associated with impaired endothelial-dependent vasodilation,and adponectin improves endothelial dysfunction through enhancing endothelial nitric oxide(NO) production,suppressing reactive oxygen species generation,and downregulating vascular inflammatory signaling cascade,thus adiponectin may be beneficial to prevention and treatment of MS and CAD.