Aim To study the modern biological intention of theory "For those people whose heart is hurt we should mediate the nutrient and the defensive" and the function of Guizhi Tang on improving microcirculation in rat experimental hyperlipemia and myocardial ischemia. Methods The early changes of hyperlipid and atherosclerosis are caused by utilizing multiple factors including feeding hyperlipid,propylthiouracil and high doses of vitamine D3(VD3).Based on the above,the myocardial ischemia model was established by injecting high doses of pituitrin.Measuring the total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDLC) and low density lipoprotein cholesterol(LDLC) in the 6th,12nd and 18th week respectively.Determine blood viscosity(low,middle and high shear rate),plasma viscosity,hematocrit,erythrocyte aggregation index and the index of erythrocyte deformability. Results Guizhi Tang significantly improves the indexes of blood lipid metabolism,increases TC,TG and LDLC,and decreases HDLC.Guizhi Tang can notably decrease blood vicosity,blood deoxidize viscosity,plasma viscosity and relative viscosity,improve hemorheology of red blood cell. Conclusions Guizhi Tang has the marked function of inproving microcirculation.Guizhi Tang can improve myocardial blood supply,decrease the ocurrance and development of main heart and vascular disease.