Aim Association between the-1562C>T single nueleotide polymorphisms of matrix metalloprotein-9 gene and the occurrence coronary artery disease in Chinese Han population was studied. Methods Case-control studies published before 31 Dec.2010 about the association of matrix metalloprotein-9 gene-1562C>T polymorphism and coronary artery disease in Chinese Han population were searched,all the literatures were evaluated and abstracted based on the defined selection criteria by two independent investigators.Publication bias was tested by funnel plot and the odd ratios of all studies were combined dependent on the result of heterogeneity test among the individual studies.The software Review Manager(version 5.0) and Stata(version 10.0) were used for meta-analysis. Results Seven studies were analyzed,there was no publication bias in 7 reviewed studies.The summarized odds ratios of TT and CT genotype combination versus CC genotype across all 7 studies was OR= 1.47(95% CI was 1.20~1.78,P=0.0001);T genotype versus C genotype was OR=1.41(95% CI was 1.17~1.69,P=0.0002);CC genotype versus TT and CT genotype combination was OR= 0.68(95% CI was 0.55~0.82,P<0.0001);CT genotype versus CC and TT genotype combination was OR=1.45(95% CI was 1.19~1.77,P=0.0002). Conclusions In Chinese Han population,-1562C>T polymorphism in matrix metalloprotein-9 gene is associated with susceptibility of coronary artery disease and T allele might be a risk factor for coronary artery disease.