Endothelial lipase (EL) is a new identified member of the lipase family, which includes lipoprotein lipase (LPL) and hepatic lipase (HL).EL is a phospholipase that plays an important role in lipoprotein metabolism, mainly regulation of plasma high density lipoprotein (HDL) metabolism and HDL cholesterol (HDLC) levels.Previous data has been reported that inhibition of EL in humans expected to increase the HDLC level.However, an important challenge is to determine how EL affects HDLC levels, reverse cholesterol transport (RCT) and progression of atherosclerosis (As).