AimTo investigate the value of myeloid-related protein (MRP) in the early diagnosis of acute coronary syndromes (ACS).Methods81 patients were sent to the hospital within three hours of acute chest pain in this study.These patients had undergone coronary angiography.According to final clinical diagnosis, patients were designated as ACS group and non-ischemic chest pain (NICP) group.Blood samples were detected for MRP in the chest pain 0-3 h, 3-6 h, 6-12 h time periods.Compare different time, different ways of MRP sampling variation to evaluate the value of MRP in the clinical diagnosis of ACS.ResultsMRP difference of ACS group had statistical significance compared with NICP group in the chest pain 0-3 h, 3-6 h and 6-12 h time periods (p<0.05).13 cases of ACS coronary artery MRP levels difference were statistically significant compared with venous blood MRP levels (p<0.05).Receiver operating characteristic curve (ROC curve) analysis was used to determine the cut-off value of this assay for identifying individuals with ACS from NICP, sensitivity and specificity at the optimal cut-off value of 8.5 mg/L were 60.7% and 95.0%.The area under ROC curve was 0.898 (95%CI 0.815-0.981).ConclusionsMRP had high sensitivity in the diagnosis of ACS.MRP can be regarded as a early diagnosis biochemical marker of ACS.