AimTo explore the clinical effects of hemoperfusion treatment on hyperlipidemia.Methods We collected 36 cases of hyperlipidemia patients, observed the cilincal indices change of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC), fibrinogen and so on before and after hemoperfusion.ResultsAfter hemoperfusion, total cholesterol, triglyceride, low density lipoprotein cholesterol and fibrinogen all decreased significantly, the differences were statistically significant (p<0.05).ConclusionsHemoperfusion cartridge has a strong function to eliminate blood lipid.Hemoperfusion technique is effective in treatment for hyperlipidemia. It’s one of the effective methods to treat hyperlipidemia.