AimTo study the relationship between apolipoprotein C3 gene C3175G polymorphism and overweight-obesity in male, as well as the risk factors of overweight-obesity.MethodsA total 154 normal weight subjects (control group) and 184 overweight-obese subjects(case group) were selected from one hospital in Chongqing during the period of May, 2008 to Sep, 2008.PCR-RFLP was applied to analyze the polymorphism, and logistic regression was used for the analysis of the risk factors of overweight-obesity.ResultsGenotype frequeney distribution of CC,CG and GG were 51.78%, 39.94%, 8.28% respectively, C and G allele frequencies were 71.75% and 28.25%.There was no significant difference of CC genotype, CG genotype, GG genotype and C allele, G allele between case group (47.28%, 44.57%,8.15%, 69.57%, 30.43%) and control group(57.14%, 34.42%, 8.44%, 74.35%,25.65%).In each group, there was no significant difference for the level of age, serum total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) between the 2 C3175G genotypes, except waist-hip ratio (WHR), triglyceride (TG) between the 2 C3175G genotypes in control group.The logistic regression analysis showed that TG may be the risk factor of overweight-obesity.ConclusionThe polymorphism of Apolipoprotein C3 gene C6175G may not be associated with overweight-obesity, but the persons with CC gene type are more likely to suffer from central obesity.