Diabetes which is due to absolutely lack of insulin(Type Ⅰ diabetes) or just relatively lack of insulin (Type Ⅱ diabetes) in vivo is a metabolic syndrome, and one of its main features is hyperglycemia.Now the optimized treatment of diabetes is insulin therapy, but the role of high levels of insulin on atherosclerosis remains controversial because diabetes were often complicated by atherosclerosis.Therefore, it is of importance in diabetic atherosclerosis therapy to illustrate the effect of high level of insulin on the cellular lipid balance in hyperglycemia condition.