AimTo investigate the association between ambulatory pulse pressure and carotid-radial pulse wave velocity (crPWV) in elderly patients with essential hypertension.MethodAccording to the results of 24 h ambulatory pulse pressure (APP), 229 patients were divided to APP≥60 mmHg group (n＝117) and APP＜60 mmHg group (n＝112), crPWV, blood glucose and lipid profiles were recorded.ResultsThe crPWV of APP≥60 mmHg group was significantly higher than APP＜60 mmHg group (11.5±1.4 m/s vs 10.3±1.2 m/s, p<0.01).Pearson relation analysis showed that crPWV level positively correlated with age, systolic blood pressure (SBP), fasting blood glucose (FBG), total cholesterol (TC), low density lipoprotein cholesterol (LDLC), 24hSBP, dSBP, nSBP, 24hPP, dPP, nPP (r＝0.302, 0.248, 0.224, 0.306, 0.365, 0.466, 0.492, 0.372, 0.552, 0.546, 0.488, all p<0.01).Multiple linear regression showed that 24hPP were significant and independent factor for crPWV in elderly patients with essential hypertension.ConclusionThe study showed that 24hPP was closely related with atherosclerosis in elderly patients with essential hypertension.