AimTo explore the correlation between serum γ-glutamyl transferase (γ-GT) and blood pressure.Methods1480 subjects were enrolled in the cross-sectional study, and standard questionnaire was used to collect information on smoking, alcohol intake and medication.Fasting blood was drawn to test γ-GT, serum glucose, liver and renal function, and body weight, body height and blood pressure were measured.Results1480 subjects included 886 male and 594 female with age range from 20 to 84 years old.By Pearson correlation analyses, γ-GT was positively correlated with systolic blood pressure, diastolic blood pressure, total cholesterol, serum glucose, low density lipoprotein cholesterol, serum uric acid, serum creatinine and body mass index, and negatively correlated with high density lipoprotein cholesterol.Compared with the lowest quartile, the highest quartile had significantly higher level of systolic blood pressure, diastolic blood pressure, total cholesterol, serum glucose, alanine aminotransferase and aspartate aminotransferase.After adjustment of sex, age, body mass index, current smoking, current alcohol intake, Logistic regression analysis indicated that there was a 74% higher risk of hypertension when compared the highest quartile with the lowest quartile (OR=1.74, 95% CI was 1.13～2.68, p=0.01).Conclusionγ-GT was positively correlated with blood pressure and can predict hypertension in Chinese.