AimTo evaluate the plasma epoxyeicosatrienoic acids（EET） levels in patients with coronary heart disease，in order to investigate the relationship between EET and high sensitivity C-reactive protein（hs-CRP） and blood lipoprotein.MethodsPlasma samples of peripheral venous blood of 30 patients and 30 controls were drawn.Enzyme-linked immunosorbent assay(ELISA) was used to measure the plasma EET levels.hs-CRP, total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDLC), and low density lipoprotein-cholesterol (LDLC) levels were measured with a Hirachi 7170A analyzer.ResultsThe levels of EET (60.01±35.06 μg/L) were significantly lower in patients with coronary heart disease compared with those in control group (88.07±33.60 μg/L,p<0.05),and the EET levels were inversely correlated with hs-CRP（r=－0.286, p=0.027）.ConclusionsThe levels of EET were significantly lower in patients with coronary heart disease, and the levels of EET were inversely correlated with hs-CRP.It is suggested that the decrease of plasma EET might be involved in the atherosclerosis inflammatory process.