AimTo explore the relationship between ankle-brachial index (ABI) and arterosclerosis in patients with non-dialysis chronic kidney disease (CKD).MethodsAs a cross-sectional study, 118 patients with diagnosis of non-dialysis CKD (stage 1-5) were selected in our hospital from October 2008 to October 2009.Clinical data were recorded, including sex, age, height, weight, smoking status, blood pressure (BP), fasting glucose, high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC) and renal function.Estimated glomerular filtration rate (eGFR) was calculated by Modification of Diet in Renal Disease Study equation.ABI values were determined with a Dopper prober.ResultsAccording to eGFR, all patients were divided into 5 groups as CKD stage 1 group to CKD stage 5 group.Compared with CKD stage 1 group, ABI values were significantly decreased in CKD stage 3 group, stage 4 group and stage 5 group (all p<0.01).There was no difference between CKD stage 1 group and stage 2 group (p>0.05).ABI value was significantly decreased with gradual decline of eGFR level (p<0.01).Multiple regression analysis showed that age, diabetes, hypertension and eGFR were risk factors for the ABI value (p<0.01).ConclusionsRenal dysfunction is an independent risk factor for arterosclerosis. Decline of eGFR was closely related with the degree of arterosclerotic lesions. ABI can be used as important clinical indicators of arterosclerosis in patients with CKD.