AimTo contrast inflammatory level and safety of different doses atorvastatin (lipitor) treatment group, and to find basis for lipid-drugs to use in acute ST-segment elevation myocardial infarction (STEMI) reasonably.Methods111 patients with STEMI were divided into two groups according to different doses of atorvastatin after percutaneons coronary intervention: 40 mg/d treatment group, 20 mg/d treatment group.The therapeutical effect was tested including inflammatory factors,lipid-level and UCG of preoperative and postoperative 1 month, and including hepatic function and renal function of preoperative and postoperative 1 month.ResultsThe lipid-lowering,anti-inflammatory,improving left venticular function of atorvastatin 40 mg treatment group were better than the atorvastatin 20 mg treatment group, but the side effect had no difference between the two groups.ConclusionsIn China, atorvastatin 40 mg/d in STEMI after percutaneons coronary intervention may be safe and effective.