AimTo investigate the relationship between serum resistin level and insulin resistance (IR) in the patients with acute cerebral infarction (ACI).MethodsFasting serum resistin and insulin (INS) levels were determined by ELISA in 68 patients with ACI and 40 healthy control subjects, the correlation among resistin, insulin resistance index (IRI) and other subjects were analyzed.ResultsCompared with the control subjects, there were significantly higher fasting serum resistin, insulin level and IRI (P<0.01) and lower QUICKI, high density lipoprotein cholesterol (HDLC) in the ACI patients (P<0.05).There was a positive correlation between resistin and body mass index (BMI), insulin, IRI and negative correlation between resistin and QUICKI, HDLC (P<0.05).Resistin, IRI, QUICKI, blood pressure and age were the major risk factors of ACI by Logistic (OR＝3505, 2222, －0.589, 5367 and 2481).ConclusionsIR may exist in the patients with ACI and serum resistin level may be associated with IR.