AimTo investigate the risk factors of cardiac valve calcification in non-dialysis uremic patients.MethodsEchocardiographic examination was performed to detect the calcificaion in 88 non-dialysis uremic patients.Patients were divided into two groups based on the echocardiographic, one as valve calcification, and the other as valve non-calcification.The blood biochemical indicators were collected, serum parathyroid hormone (iPTH) was detected by radioimmunology.Thirty healthy cases were selected for normal control group.Serum fetuin-A was measured by enzyme-linked immunosorbnent assay (ELISA) in both of the study group and control group.The calcification risk factors were analyzed by binary logistic regression.ResultsOf the 88 patients studied, cardiac valve calcification was found in 25 patients, aortic valve calcification in 21 patients, mitral valve calcification in 4 patients, aortic and mitral valve calcification in 2 patients.Serum fetuin-A was lower in study group than in normal control group(P<0.05).Age, serum phosphorus, calcium phosphorus product(Ca×P), C-reaction protein (CRP) and iPTH were higher in calcification group than in non-calcifiation group,while serum fetuin-A was lower (P<0.05).Binary Logistic regression analysis showed that age (B=3732, P=0.015), Ca×P (B=1255, P=0.003), P (B=1774, P=0.003), CRP (B=1503, P=0.025) and iPTH (B=0.832, P=0.017) were the risk factors of cardiac valve calcification.Fetuin-A (B=－0.59, P=0.043) was negatively correlated with cardiac valve calcification.Fetuin-A was negatively correlated with CRP (r=－0.545, P=0.000).ConclusionsThe cardiac valve calcification is prevalent in non-dialysis uremic patients, of which aortic valve calcification is more common than mitral valve calcification.The risk factors include age, Ca×P, P, inflammation, iPTH.Serum fetuin-A is the valve calcification inhibitors and negatively correlated with CRP.