Ischemic postconditioning had been observed to reduce infarct size and cell apoptosis on myocardial ischemia-reperfusion injury, and was also associated with a reduction in endothelial cell dysfunction and so on. Postconditioning is a fairly simple strategy, and seems possible to be applied in patients. We will review the advancements of protective effects and the mechanisms in myocardial ischemic postconditioning. The operability of postconditioning in clinical application makes it the focus and hotspots in the field of cardiovascular research in recent years. We will review the clinical application and study progress of myocardial ischemic postconditioning.