Aim To investigate the association of endothelial microparticle (EMP) and brachial-ankle pulse wave velocity (baPWV) in patients with stable coronary artery disease (CAD). Methods 50 patients with stable coronary artery disease and 20 healthy volunteers were studied. Flow cytometer was used to measure levels of EMP (CD31^＋/CD42b^－) in circulation and baPWV was measured to assess the status of arterial elasticity. Results The levels of EMP were higher in patients with stable CAD than that of healthy volunteers (1 748.4±102.1 particles/μL vs 847.4±86.4 particles/μL, P<0.01), and baPWV was faster in patients with stable CAD than that of healthy volunteers (1 931.1±328.3 cm/s vs 1 532.1±147.3 cm/s, P<0.01). There was a positive correlation between the level of EMP and baPWV in stable CAD (r＝0.42, P<0.01). Conclusions Patients with stable CAD had higher EMP and faster baPWV than those of healthy volunteers, and there was positive correlation between EMP and baPWV. EMP was an independent influencing factor to arterial elasticity.