Platelet-derived microparticle （PMP） is small plasma membrane vesicles shed from platelets upon their activation or apoptosis. Not only PMP is the important prothrombotic and proinflammatory substance, but also its function is used as vehicle for many kinds of bioactive substances mediating intracellular transfer of biological information. PMP is involved in regulation of coagulation, immune inflammation and vascular function, playing key roles in the occurrence and development of atherosclerosis and possibly becoming a new bio-marker and therapeutic target of cardiovascular diseases. This review will mainly focus on biological characteristics of PMP and its roles in cardiovascular diseases.